Brighton will be without defender Gordan Greer and midfielder Glenn Murray who are both suspended.
Defender Lewis Dunk (foot) and goalkeeper Peter Brezovan (wrist) also miss out but Ashley Barnes is expected to start up front.
Swindon Town manager Danny Wilson told BBC Wiltshire: "There was a cause for concern when we first came back as whether that hangover would be there from the play-offs but we dispelled that straight away.
"It'll be a big game for us and they're no mugs there [at Brighton] with all the players they've got and their aspirations are obviously far greater than last year.
"The way Gus [Poyet] wants his team to play I'd like to think it'll be a fairly attractive game for the fans as well."
Brighton manager Gus Poyet told BBC Sussex: "We lost the two games against them last year so that shows you how difficult it will be. Maybe we deserved a little bit better in both games. We should be better this year.
"It's a different game; it's a new season. The first game is always difficult but we're going there with a chance to win the game I think."
Source: BBC Sport
Source: BBC Sport